Our core helps investigators evaluate promising novel therapeutic agents and diagnostics, as well as existing therapeutics being considered for novel uses (repurposing), through continued development and deployment of relevant animal models and in vitro cell lines and tissue models. We provide several services to investigators to suit many needs, including those who may lack laboratory facilities and/or expertise for conducting experiments associated with preclinical therapeutic hypothesis testing.
What do we provide?
- Expertise in preclinical evaluation of new therapeutics (both in vitro and in vivo)
- Access to animal models and laboratory facilities
- Standard procedures and GLP-like documentation
2018 Outstanding Core
The Developmental Therapeutics Core (DTC) was one of three facilities to win the 2018 Outstanding Core Facility Award, bestowed on facilities that place in the top 10% here at Northwestern.
Proliferation and Apoptosis Assays
Exploratory PK and Tox
Device Implantation and Monitoring
Tarry Building Room 2711
Irawati (Angki) Kandela
Silverman Hall B729
Collaborate with the CoreLooking for expertise? Want access to advanced, preclinical animal models of disease? Our lab is here to help.
Location and Collaboration
Our core is located on the Evanston campus in Silverman Hall’s west basement complete with dedicated wet lab, cell culture, storage, and office space, and is adjacent to central animal facilities.
We actively works with users across both the Evanston and Chicago campuses, providing a local presence and collaborative interaction to help guide:
- study design including appropriate model selection
- study implementation
- interpretation of results
- preparation of results for presentation in manuscripts and grant applications
Seamless collaboration between campuses in enabled through free daily courier service to transfer samples from Silverman Hall to and from the Chicago campus as well as free weekly specialized transport of animals by CCM.
We provide an initial consultation regarding model selection, experimental design, and types of analyses to be performed. A study protocol and cost estimate are generated and approved by the user. At the completion of the study, data is collected and analyzed with a final report furnished in 1-2 weeks.
PLEASE NOTE: Our core maintains several blanket ACUC protocols to fit various user needs. However, an amendment is typically required to add the test substance and administration procedure. These require approximately 30 days to be approved. Your study cannot begin without approval if required.
Support of core facilities depends in part on proper recognition of contributions of core scientists on grants and publications. Please refer to our publication guidelines for users here. All manuscripts and grants presenting work supported by DTC should include the following acknowledgment:
“This work was supported by the Developmental Therapeutics Core at Northwestern University and the Robert H. Lurie Comprehensive Cancer Center support grant (NCI CA060553).”
We are always happy to help you obtain funding to further your research. Below are some funding mechanisms at Northwestern to help support your work with us:
Chemistry of Life Processes Institute
CLP Cornew Innovation Fund
The goal of this funding mechanism is to jump start new transdisciplinary research that is collaborative in nature by enabling investigators to gather preliminary data in support of external funding applications. This mechanism is available to all faculty formally affiliated with the Chemistry of Life Processes Institute. Awards (up to $50,000 for new team science) are made annually with applications solicited in early fall.
Northwestern University Clinical and Translational Sciences Institute (NUCATS)
Voucher and Pilot Programs
Voucher (tier 1: $2,500) and Pilot (tier 2: $20,000) awards are designed to accelerate research by providing rapid, targeted funding to address small but critical gaps in clinical and translational research work. Vouchers are awarded on a rolling basis, and pilots are 1-2 times per year.
Dixon Translational Research Grant
The Dixon Translational Research Grants initiative seeks proposals for highly innovative, multi-disciplinary clinical and translational research collaborations to accelerate the identification and implementation of new treatments that will improve human health.
Robert H. Lurie Comprehensive Cancer Center (RHLCCC)
H Foundation NCI Stimulus Awards
The H Foundation Stimulus Award is restricted to members of the LCC basic sciences research program and is designed to assist faculty in procurement of NCI-funded R01 grants. The applicant must have submitted a first-in-career R01 application to the NCI that was scored, but not funded, OR received a score near the payline on a competitive renewal application
Office for Research
Bridge Funding Support for Research Programs
The Bridge Funding Support program provides interim funding to continue federally funded research projects that have a demonstrated likelihood of continued federal funding pending resubmission of a grant proposal. Requires matching funds from PI’s department/school.
Core Facilities Development Pilot Grant Program (CFaD)
The CFaD Pilot Grant program is an internal, peer-reviewed grant opportunity that supports developing methods or techniques within cores that directly impacts multiple principal investigators and are likely to lead to increased usage of cores in the future. Funds can be used to purchase consumables, services, staff and instrument time in one or more core facilities. Maximum awards are $15,000 and should be completed within 6 months of award notification.