Rodent exploratory pharmacokinetics (PK)

The need to understand the distribution and clearance of the drug in the animals is very important in the process of drug development.  The DTC performs exploratory pharmacokinetics (PK) studies for PIs who are interested in understanding the fate of a drug in vivo.  DTC can perform the in-life phase of the study and collect blood and tissue for analysis.  For small molecules, it collaborates with the Mary Beth Donnelly Clinical Pharmacology Core, which develops LC/MS assays and carries out analysis.  For other types of drugs, e.g. biologics, the DTC directly performs assay development, validation and analysis of samples.