Translational and Preclinical Services

The Developmental Therapeutics Core (DTC) provides an operational laboratory that supports translational projects and fulfills the needs of the research community for exploratory drug development work. The aim is to rapidly and efficiently advance novel therapeutic interventions from basic research to the clinic. The facility is located on the Evanston campus in Silverman Hall.

Support of core facilities depends in part on proper recognition of contributions of core scientists on grants and publications.  Please refer to our publication guidlines for users here.  All manuscripts and grants presenting work supported by DTC should include the following acknowledgment:

 

“This work was supported by the Developmental Therapeutics Core at Northwestern University and the Robert H. Lurie Comprehensive Cancer Center support grant (NCI CA060553).”

 

Proliferation and Apoptosis Assays

More than 200 cell lines are available for in vitro testing, including for determination of drug IC50 values. DTC is also able to assess the effects of therapeutics on cells grown in 3D culture or on organoid cultures.

Therapy-Response Experiments

Core personnel provide expert guidance in determining the most appropriate models for evaluating the anti-cancer activities of compounds and biologicals of interest. Services include experimental design consultation, animal procurement, inoculating mice with the cells obtained from culture or from PDX, therapy administration to animals, and monitoring tumor growth and response to treatment.

Exploratory PK and Tox

Exploratory pharmacokinetics analysis can be incorporated into therapy-response experiments through organ and tissue harvest of treated animal subjects at pre-determined time points during treatment. Many DTC projects require and include determination of therapeutic maximum tolerated dose (MTD) prior to initiating a therapy-response experiment with 7-day Repeated Dose also offered.

PDX models accessible through the core

PDX models offer the closest approximation to the clinical setting for testing cancer therapies, other than immunotherapies.  Consider working with us and our Patient-Derived Xenograft Tumor Repository to help translate your research.

Collaborate with the Core

Looking for expertise?  Want access to advanced, preclinical animal models of disease?  Our lab is here to help.

FY19 Core Facility Pricing

In Vitro Services

Service Northwestern and CBC External Academic
Cell Lines
Per Line/Availability
$275 $300
Proliferation Assay
1 cell line, 1 compound
$100 $125
Proliferation Assay
up to 5 concentrations
$375 $385
Spheroid Assay  $1,380 $1,600

In Vivo Services

Service Northwestern and CBC External Academic
Toxicity
Per animal.
$300 $350
7-Day Repeated Dose Toxicity $350 $450
Pharmacokinetics
Per animal.
$75 $150
Dosing
Per animal.
$45 $50
Tumor Model Efficacy
Cell line xenograft, n=40
dosing and report included, weekly
$2,000 $2,200
PDX Model Efficacy
PDX, n=40
dosing and report included, weekly
$2,000 $2,200
Xenograft Setup $130 $175
Device Implantation $200 $300

 

Other

Service Northwestern and CBC External Academic
Consultation
Per hour.
$130 $150
Protocol Creation ACUC. $500 $600
Protocol Addendum $200 $250
Shipping
Per shipment.
$65 $65